4-Methylphenyl isocyanate → N-(4-Methylphenyl)-N'-[4-(5-oxo-4,5-dihydropyrazin-2-yl)phenyl]urea

HRID 542471Notes

Reaction equation

HRID 542471 reaction equation
[C:1]1([CH3:10])[CH:6]=[CH:5][C:4]([N:7]=[C:8]=[O:9])=[CH:3][CH:2]=1.[NH2:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[N:19]=[CH:20][C:21](=[O:24])[NH:22][CH:23]=2)=[CH:14][CH:13]=1>>[C:1]1([CH3:10])[CH:6]=[CH:5][C:4]([NH:7][C:8](=[O:9])[NH:11][C:12]2[CH:13]=[CH:14][C:15]([C:18]3[N:19]=[CH:20][C:21](=[O:24])[NH:22][CH:23]=3)=[CH:16][CH:17]=2)=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 693254-Methylphenyl isocyanateHCID 123580285-(4-Aminophenyl)pyrazin-2(1H)-one

Product 1

HCID 20208665N-(4-Methylphenyl)-N'-[4-(5-oxo-4,5-dihydropyrazin-2-yl)phenyl]urea

Procedure

Using a procedure similar to that of Example 17 p-tolyl isocyanate is reacted with 5-(4-aminophenyl)-2(1H)-pyrazinone (or its hydrobromide salt) to give 5-[4-(3-p-tolylureido)phenyl]-2(1H)-pyrazinone.

Sources & evidence

ORD record
ord-07ad089960c047d5a5a1d5c51badf701
Source dataset
uspto-grants-1987_04
Patent number
US04657906

Reaction notes

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