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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 542471Generated: October 31, 2026

4-Methylphenyl isocyanate → N-(4-Methylphenyl)-N'-[4-(5-oxo-4,5-dihydropyrazin-2-yl)phenyl]urea

https://huagongshe.com/reaction/542471

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Methylphenyl isocyanateHCID 69325—
Reactant5-(4-Aminophenyl)pyrazin-2(1H)-oneHCID 12358028—
ProductN-(4-Methylphenyl)-N'-[4-(5-oxo-4,5-dihydropyrazin-2-yl)phenyl]ureaHCID 20208665—

Reaction Steps

Using a procedure similar to that of Example 17 p-tolyl isocyanate is reacted with 5-(4-aminophenyl)-2(1H)-pyrazinone (or its hydrobromide salt) to give 5-[4-(3-p-tolylureido)phenyl]-2(1H)-pyrazinone.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04657906
Source datasetuspto-grants-1987_04
ORD IDord-07ad089960c047d5a5a1d5c51badf701
Source noteuspto-grants-1987_04