Potassium Carbonate → 5-methyl-2-(propan-2-ylamino)-3,1-benzoxazin-4-one

HRID 542499Notes

Reaction equation

HRID 542499 reaction equation
Cl.[CH:2]([NH:5][C:6]1[O:11][C:10](=[O:12])[C:9]2[C:13]([CH3:17])=[CH:14][CH:15]=[CH:16][C:8]=2[N:7]=1)([CH3:4])[CH3:3].C(=O)([O-])[O-].[K+].[K+]>CCOCC>[CH:2]([NH:5][C:6]1[O:11][C:10](=[O:12])[C:9]2[C:13]([CH3:17])=[CH:14][CH:15]=[CH:16][C:8]=2[N:7]=1)([CH3:4])[CH3:3]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 20208485HCID 20208485, compound

Product 1

HCID 98158285-methyl-2-(propan-2-ylamino)-3,1-benzoxazin-4-one

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

1.0 g of 2-isopropylamino-5-methyl-4H-3,1-benzoxazin-4-one HCl suspended in 50 ml of ether is stirred with a twofold stoichiometric excess of dilute aqueous potassium carbonate solution until the salt is completely dissolved. The organic layer is then separated, washed twice with water, dried over magnesium sulfate and evaporated to yield 2-isopropylamino-5-methyl-4H-3,1-benzoxazin-4-one as the free base.

Workup

  1. dissolutionis completely dissolved
  2. customThe organic layer is then separated
  3. washwashed twice with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated

Sources & evidence

ORD record
ord-c2c5a0de98144dba954e5555c74c2695
Source dataset
uspto-grants-1987_04
Patent number
US04657893

Reaction notes

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