反应详情

A mixture containing 5.6 g of 5-bromo-1,6-naphthyridin-2(1H)-one, 100 ml of dimethylformamide and 6.9 g of 1,2,4-triazole was refluxed on an oil bath for 21 hours and then allowed to cool. The separated solid was collected, washed with ethanol and dried in a vacuum oven at 90° C. to yield 2.8 g of 5-(1H-1,2,4-triazol-1-yl)-1,6-naphthyridin-2(1H)-one, m.p.>300° C.

1. temperaturewas refluxed on an oil bath for 21 hours
2. temperatureto cool
3. customThe separated solid was collected
4. washwashed with ethanol
5. customdried in a vacuum oven at 90° C.