Hydrochloric Acid → HCID 13732597, compound

HRID 542556Notes

Reaction equation

HRID 542556 reaction equation
[C:1]([C:9]1[C:10]([O:20][N:21]=C(C)C)=[C:11]2[CH:17]=[N:16][N:15]([CH2:18][CH3:19])[C:12]2=[N:13][CH:14]=1)(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>C(O)C>[CH2:18]([N:15]1[C:12]2=[N:13][CH:14]=[C:9]3[C:1]([C:2]4[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=4)=[N:21][O:20][C:10]3=[C:11]2[CH:17]=[N:16]1)[CH3:19]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 13732595HCID 13732595, compound

Product 1

HCID 13732597HCID 13732597, compoundYield 80.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5-Benzoyl-1-ethyl-4-isopropylideneaminooxy-1H-pyrazolo [3,4-b]pyridine (2.50 g) was refluxed for 2 hours in a mixture prepared from 100 ml of 5% hydrochloric acid and 15 ml of ethanol. The reaction mixture was then extracted into ether and washed consecutively with 5% sodium hydroxide solution and water. Evaporation of the organic phase gave 1.65 g of product. An analytical sample recrystallized from ethyl acetate/methanol had mp 151°-153° C.

Workup

  1. extractionThe reaction mixture was then extracted into ether
  2. washwashed consecutively with 5% sodium hydroxide solution and water
  3. customEvaporation of the organic phase

Sources & evidence

ORD record
ord-b9231a7360f8456d891a64949e1eff50
Source dataset
uspto-grants-1987_04
Patent number
US04658029

Reaction notes

Loading…