HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 6-Chloro-1,3-dihydroindol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 6-Chloroindoline-2,3-dione | HCID 241331 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6-Chloro-1,3-dihydroindol-2-one | HCID 736344 | 42.5% |
Reaction Steps
Reaction of 36.2 g of 6-chloroisatin with hydrazine hydrate followed by sodium ethoxide in ethanol, substantially according to C above, afforded 14.2 g of 6-chloro-2-oxindole, mp 196°-198° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04658037 |
| Source dataset | uspto-grants-1987_04 |
| ORD ID | ord-4f4e8e0653434754833e7f1234dc3253 |
| Source note | uspto-grants-1987_04 |