Acetic Anhydride → HCID 54300004, compound

HRID 54264Notes

Reaction equation

HRID 54264 reaction equation
[CH2:1]([NH:3][C:4]1[N:9]=[C:8]([NH2:10])[C:7]([CH:11]=[CH:12][CH:13]([C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=2)[CH3:14])=[C:6]([CH3:22])[N:5]=1)[CH3:2].[C:23](OC(=O)C)(=[O:25])[CH3:24]>CN(C)C1C=CN=CC=1>[CH2:1]([NH:3][C:4]1[N:9]=[C:8]([NH:10][C:23]([CH3:24])=[O:25])[C:7]([CH:11]=[CH:12][CH:13]([C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=2)[CH3:14])=[C:6]([CH3:22])[N:5]=1)[CH3:2]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 540338362-Ethylamino-4-amino-6-methyl-5-[3-(4-chlorophenyl)-1-butenyl]pyrimidine2×

Product 1

HCID 54300004HCID 54300004, compound

Reagents, catalysts & solvents 1

HCID 142844-(Dimethylamino)pyridineCatalyst

Procedure

This compound is prepared in a manner analogous to that of Example 8, using 0.32 gram (0.001 mole) 2-ethylamino-4-amino-6-methyl-5-[3-(4-chlorophenyl)-1-butenyl]pyrimidine (Compound 47--prepared in Example 7) and 0.01 gram (catalyst) of 4-dimethylaminopyridine in 5 mL of acetic anhydride, yielding 2-ethylamino-4-methylcarbonylamino-6-methyl-5-[3-(4-chlorophenyl)-1-butenyl]pyrimidine.

Workup

  1. customThis compound is prepared in a manner analogous to that of Example 8

Sources & evidence

ORD record
ord-cdff0504e5894620b6361565e2b8d489
Source dataset
uspto-grants-1997_04
Patent number
US05622954

Reaction notes

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