HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 542697Generated: October 30, 2026
Hydrochloric Acid → 2-(2-Pentyl-5-pyridyl)-thiophene-5-carbonitrile
https://huagongshe.com/reaction/542697
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Cyanogen | HCID 9999 | — |
| Reactant | 5-Chloro-2-(2-pentyl-5-pyridyl)-thiophene | HCID 20206767 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 2-(2-Pentyl-5-pyridyl)-thiophene-5-carbonitrile | HCID 20206706 | — |
Reaction Steps
A mixture of 26.6 g of 5-chloro-2-(2-pentyl-5-pyridyl)-thiophene, 10 g of Cu2 (CN)2, 120 ml of pyridine and 60 ml of N-methylpyrrolidone is heated at 150° for 2 hours. It is cooled, a solution of 120 g of FeCl3.6 H2O in 600 ml of 20% strength hydrochloric acid is added and the mixture is warmed at 70° C. for 1.5 hours, with stirring, and worked up in the customary manner to give 2-(2-pentyl-5-pyridyl)-thiophene-5-carbonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04659503 |
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| Source dataset | uspto-grants-1987_04 |
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| ORD ID | ord-2fd99d3e0cf648c6850d194d0b4ef8fb |
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| Source note | uspto-grants-1987_04 |
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