Hydrochloric Acid → HCID 13826768, compound

HRID 542716Notes

Reaction equation

HRID 542716 reaction equation
[Cl:1][C:2]1[CH:29]=[CH:28][C:5]([C:6]([NH:8][C:9]2[CH:10]=[C:11]3[C:16](=[C:17]([N:19]4[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][OH:27])[CH2:21][CH2:20]4)[N:18]=2)[N:15]=[CH:14][CH:13]=[CH:12]3)=[O:7])=[CH:4][CH:3]=1.Cl.CCOCC>C(O)C>[ClH:1].[Cl:1][C:2]1[CH:29]=[CH:28][C:5]([C:6]([NH:8][C:9]2[CH:10]=[C:11]3[C:16](=[C:17]([N:19]4[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][OH:27])[CH2:21][CH2:20]4)[N:18]=2)[N:15]=[CH:14][CH:13]=[CH:12]3)=[O:7])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 13826767HCID 13826767, compound

Product 1

HCID 13826768HCID 13826768, compoundYield 188.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Dissolved in 20 ml of ethanol was 4.1 g of 6-(4-chlorobenzoylamino)-8-[4-(2-hydroxyethyl)-1-piperazinyl]-1,7-naphthyridine, followed by a gradual addition of HCl-saturated ethanol while stirring the reaction system under ice-cooling. Thereafter, 200 ml of ether was added further and the resultant crystals were collected by filtration. The crystals were thoroughly washed with ether and then dried, thereby obtaining 4.2 g of the hydrochloride (Compound No. 29) as light yellowish crystals.

Workup

  1. temperaturecooling
  2. filtrationthe resultant crystals were collected by filtration
  3. washThe crystals were thoroughly washed with ether
  4. customdried

Sources & evidence

ORD record
ord-91b8216279634f8090fd6a85c39713eb
Source dataset
uspto-grants-1987_04
Patent number
US04659710

Reaction notes

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