Ammonium Hydroxide → 3-acetyl-8-methoxy-7-sulfamoyl-2,3,4,5-tetrahydro-1H-3-benzazepine

HRID 542723노트

반응식

HRID 542723 반응식
[C:1]([N:4]1[CH2:10][CH2:9][C:8]2[CH:11]=[C:12]([O:19][CH3:20])[C:13]([S:15](Cl)(=[O:17])=[O:16])=[CH:14][C:7]=2[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[OH-].[NH4+:22]>>[C:1]([N:4]1[CH2:10][CH2:9][C:8]2[CH:11]=[C:12]([O:19][CH3:20])[C:13]([S:15](=[O:17])(=[O:16])[NH2:22])=[CH:14][C:7]=2[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

참가 물질

3

반응물 2

HCID 14923Ammonium HydroxideHCID 138533503-acetyl-7-chlorosulfonyl-8-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine

생성물 1

HCID 138533513-acetyl-8-methoxy-7-sulfamoyl-2,3,4,5-tetrahydro-1H-3-benzazepine

실험 절차

3-Acetyl-7-chlorosulfonyl-8-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine (3 g, 0.007 m) was treated with concentrated ammonium hydroxide (10 ml), stirred for 2 hours and filtered to give 3-acetyl-8-methoxy-7-sulfamoyl-2,3,4,5-tetrahydro-1H-3-benzazepine, m.p. 260°-263°.

후처리

  1. filtrationfiltered

출처 및 근거

ORD 기록
ord-82bbe709232a4491a3065977726b067f
출처 데이터셋
uspto-grants-1987_04
특허 번호
US04659706

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