Hydrochloric Acid → 8-methoxy-7-sulfamoyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

HRID 542724Notes

Reaction equation

HRID 542724 reaction equation
C([N:4]1[CH2:10][CH2:9][C:8]2[CH:11]=[C:12]([O:19][CH3:20])[C:13]([S:15](=[O:18])(=[O:17])[NH2:16])=[CH:14][C:7]=2[CH2:6][CH2:5]1)(=O)C.[ClH:21]>>[ClH:21].[CH3:20][O:19][C:12]1[C:13]([S:15](=[O:18])(=[O:17])[NH2:16])=[CH:14][C:7]2[CH2:6][CH2:5][NH:4][CH2:10][CH2:9][C:8]=2[CH:11]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 138533513-acetyl-8-methoxy-7-sulfamoyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Product 1

HCID 212428978-methoxy-7-sulfamoyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

Procedure

The sulfonamide (2.3 g, 0.007 m) was suspended in 3N hydrochloric acid and heated to reflux for 16 hours. The mixture was concentrated in vacuo and the residue crystallized from methanol to give 8-methoxy-7-sulfamoyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride, m.p. 270°-274°.

Workup

  1. temperatureheated
  2. temperatureto reflux for 16 hours
  3. concentrationThe mixture was concentrated in vacuo
  4. customthe residue crystallized from methanol

Sources & evidence

ORD record
ord-6df4459beac94f48a106c3751876e590
Source dataset
uspto-grants-1987_04
Patent number
US04659706

Reaction notes

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