Hydrogen Bromide → 8-hydroxy-3-methyl-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

HRID 542732Notes

Reaction equation

Cl.[CH3:2][N:3]1[CH2:9][CH2:8][C:7]2[CH:10]=[C:11]([O:18]C)[C:12]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:13][C:6]=2[CH2:5][CH2:4]1.[BrH:20]>>[BrH:20].[OH:18][C:11]1[C:12]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:13][C:6]2[CH2:5][CH2:4][N:3]([CH3:2])[CH2:9][CH2:8][C:7]=2[CH:10]=1

Participants

Reactant 2

HCID 260Hydrogen Bromide

HCID 212429163-methyl-8-methoxy-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

Product 1

HCID 212429438-hydroxy-3-methyl-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

Procedure

Following the procedure of Example 4, 3-methyl-8-methoxy-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3benzazepine hydrochloride was reacted with 48% hydrobromic acid to give 8-hydroxy-3-methyl-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide, m.p. 310° (decomp.).

Sources & evidence

ORD record: ord-b70bdad90d834587b5663bafc5242609
Source dataset: uspto-grants-1987_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04659706

Reaction notes

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