Hydrochloric Acid → HCID 21242958, compound

HRID 542735Notes

Reaction equation

C([N:4]1[CH2:10][CH2:9][C:8]2[CH:11]=[CH:12][C:13]([O:19][CH3:20])=[C:14]([S:15]([CH3:18])(=[O:17])=[O:16])[C:7]=2[CH2:6][CH2:5]1)(=O)C.[ClH:21]>>[ClH:21].[CH3:20][O:19][C:13]1[CH:12]=[CH:11][C:8]2[CH2:9][CH2:10][NH:4][CH2:5][CH2:6][C:7]=2[C:14]=1[S:15]([CH3:18])(=[O:17])=[O:16]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 21242923HCID 21242923, compound

Product 1

HCID 21242958HCID 21242958, compound

Procedure

Following the procedure of Example 4, 3-acetyl-7-methoxy-6-methylsulfonyl-2,3,4,5-tetrahydro-1H-3benzazepine is treated with hydrochloric acid to give 7-methoxy-6-methylsulfonyl-2,3,4,5-tetrahydro-1H-3benzazepine hydrochloride which is treated with 48% hydrobromic acid to give 7-hydroxy-6-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide.

Sources & evidence

ORD record: ord-b08acf982f574229a185f0b89df56270
Source dataset: uspto-grants-1987_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04659706

Reaction notes

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