Sodium Hydroxide → SK&F 103829

HRID 542745Notes

Reaction equation

HRID 542745 reaction equation
Br.[OH:2][C:3]1[C:4]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:5][C:6]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8][C:7]=2[CH:13]=1.[OH-].[Na+]>>[OH:2][C:3]1[C:4]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:5][C:6]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8][C:7]=2[CH:13]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 212428778-hydroxy-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

Product 1

HCID 130981SK&F 103829

Procedure

8-Hydroxy-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide is treated with one equivalent of sodium hydroxide in aqueous solution. Extracting into chloroform and evaporating gives 8-hydroxy-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine.

Workup

  1. extractionExtracting into chloroform
  2. customevaporating

Sources & evidence

ORD record
ord-d507a56eecf146f5943541a84d877583
Source dataset
uspto-grants-1987_04
Patent number
US04659706

Reaction notes

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