反应详情

7-Fluoro-1-methyl-3-(1-methyl-1H-tetrazol-5-yl)-4-quinolone (5 g) was added to a solution of sodium (0.9 g) in butanol (50 ml) and the mixture was heated at 100° for 19 hours. The mixture was poured into water (200 ml). The resulting precipitate was collected and recrystallised twice from industrial methylated spirit to give the novel compound 7-butoxy-1-methyl-3-(1-methyl-1H-tetrazol-5-yl)-4-quinolone, m.p. 187°-190°.

1. temperaturethe mixture was heated at 100° for 19 hours
2. customThe resulting precipitate was collected
3. customrecrystallised twice from industrial methylated spirit