Water → 7-butoxy-1-methyl-3-(1-methyl-1H-tetrazol-5-yl)-4-quinolone

HRID 542817Notes

Reaction equation

HRID 542817 reaction equation
F[C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:19])[C:7]([C:13]3[N:17]([CH3:18])[N:16]=[N:15][N:14]=3)=[CH:8][N:9]2[CH3:12])=[CH:4][CH:3]=1.[Na].[OH2:21]>C(O)CCC>[CH2:11]([O:21][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:19])[C:7]([C:13]3[N:17]([CH3:18])[N:16]=[N:15][N:14]=3)=[CH:8][N:9]2[CH3:12])=[CH:4][CH:3]=1)[CH2:2][CH2:3][CH3:4]

Participants

5

Reactant 3

HCID 962WaterHCID 5360545SodiumHCID 134744537-fluoro-1-methyl-3-(1-methyl-1H-tetrazol-5-yl)-4-quinolone

Product 1

HCID 134744267-butoxy-1-methyl-3-(1-methyl-1H-tetrazol-5-yl)-4-quinolone

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

7-Fluoro-1-methyl-3-(1-methyl-1H-tetrazol-5-yl)-4-quinolone (5 g) was added to a solution of sodium (0.9 g) in butanol (50 ml) and the mixture was heated at 100° for 19 hours. The mixture was poured into water (200 ml). The resulting precipitate was collected and recrystallised twice from industrial methylated spirit to give the novel compound 7-butoxy-1-methyl-3-(1-methyl-1H-tetrazol-5-yl)-4-quinolone, m.p. 187°-190°.

Workup

  1. temperaturethe mixture was heated at 100° for 19 hours
  2. customThe resulting precipitate was collected
  3. customrecrystallised twice from industrial methylated spirit

Sources & evidence

ORD record
ord-40ec6fb01e1948b7bea2781c6baf2fe8
Source dataset
uspto-grants-1987_04
Patent number
US04659718

Reaction notes

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