反应详情

A mixture of 5.5 g (0.015 mole ) of 6-bromo-N-(6-methoxy-4-methyl-8-quinolinyl)hexanamide and 3.4 g (0.03 mole) of 2,6-dimethylpiperazine in 80 ml of benzene was heated under reflux for 21 hr, treated with 2 ml of triethylamine, and heated for an additional 4 hr. The mixture was allowed to cool, diluted with water and toluene, and made strongly basic with 50% sodium hydroxide solution. The organic layer was washed, dried and concentrated to dryness in vacuo. Recrystallization from hexane containing a little toluene afforded 5 g (83%) of the title compound, mp 94°-96°.

1. temperaturewas heated
2. temperatureunder reflux for 21 hr
3. temperatureheated for an additional 4 hr
4. temperatureto cool
5. washThe organic layer was washed
6. customdried
7. concentrationconcentrated to dryness in vacuo
8. customRecrystallization from hexane containing a little toluene