反应详情

To a suspension of cysteamine hydrochloride (2.95 g, 26 mmoles) in ethanol (100 ml) was added 60% sodium hydride (oily; 2.08 g, 26 mmoles) with stirring under ice-cooling and the mixture was stirred for 5 minutes. 5-chloro-2-methylimidazo[1,2-a]pyridine (3.33 g, 20 mmoles) was added to the mixture, followed by heating at reflux for 3 hours. After the solvent was distilled off, chloroform was added to the residue which was washed with 1N-NaOH and dried over anhydrous potassium carbonate. After the solvent was distilled off, the residue was purified by column chromatography (eluent: ethyl acetate/ethanol/triethylamine=6:2:1) to obtain 2.2 g of the desired product (53.6%, brown oily product).

1. temperaturecooling
2. stirringthe mixture was stirred for 5 minutes
3. temperatureby heating
4. temperatureat reflux for 3 hours
5. distillationAfter the solvent was distilled off
6. additionchloroform was added to the residue which
7. washwas washed with 1N-NaOH
8. dry with materialdried over anhydrous potassium carbonate
9. distillationAfter the solvent was distilled off
10. customthe residue was purified by column chromatography (eluent: ethyl acetate/ethanol/triethylamine=6:2:1)