Sodium Fluoride → HCID 20207847, compound

HRID 542929Notes

Reaction equation

HRID 542929 reaction equation
[F-:1].[Na+].[CH2:3]([N:7]1[C:12](=[O:13])[N:11]([CH2:14][CH:15]([OH:18])[CH2:16]Cl)[C:9](=[O:10])[N:8]1[CH2:19][CH:20]1[O:22][CH2:21]1)[CH:4]1[O:6][CH2:5]1>CC(C)=O>[CH2:3]([N:7]1[C:12](=[O:13])[N:11]([CH2:14][CH:15]([OH:18])[CH2:16][F:1])[C:9](=[O:10])[N:8]1[CH2:19][CH:20]1[O:22][CH2:21]1)[CH:4]1[O:6][CH2:5]1

Participants

4

Reactant 2

HCID 5235Sodium FluorideHCID 20207845HCID 20207845, compound

Product 1

HCID 20207847HCID 20207847, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

2.1 g (50 mMoles of sodium fluoride were added to a solution of 1.5 g (5 mMoles) of 1,2-diglycidyl-4-(3-chloro-2-hydroxypropyl)-urazole in 100 ml of acetone and the mixture boiled for 6 hours. After the solvent had been distilled off and the residue taken up in 50 ml of methylene chloride, followed by filtration, removal of the methylene chloride by distillation and drying in an oil pump vacuum at 40° C., 1,2-diglycidyl-4-(3-fluoro-2-hydroxypropyl)-urazole, refractive index nD20 :1.4955 (colorless liquid), was obtained in a yield of 1.5 g (100%).

Workup

  1. distillationAfter the solvent had been distilled off
  2. filtrationfollowed by filtration, removal of the methylene chloride by distillation
  3. customdrying in an oil pump vacuum at 40° C.

Sources & evidence

ORD record
ord-e44497d7ad934deca2974b83896b082e
Source dataset
uspto-grants-1987_04
Patent number
US04659824

Reaction notes

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