Carbamic acid, [4-(hexylamino)-4-oxobutyl]methyl-, phenylmethyl ester → HCID 20206870, compound

HRID 543002Notes

Reaction equation

HRID 543002 reaction equation
C(O[C:9]([N:11]([CH2:13][CH2:14][CH2:15][C:16]([NH:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])=[O:17])C)=O)C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[CH2:19]([NH:18][C:16](=[O:17])[CH2:15][CH2:14][CH2:13][NH:11][CH3:9])[CH2:20][CH2:21][CH2:22][CH2:23][CH3:24]

Participants

5

Reactant 2

HCID 20206828Carbamic acid, [4-(hexylamino)-4-oxobutyl]methyl-, phenylmethyl esterHCID 178418361HCID 178418361, compound

Product 1

HCID 20206870HCID 20206870, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of the 4-(N-benzyloxycarbonyl-N-methylamino)-N-n-hexylbutyramide thus obtained (6.6 g.) in ethanol (100 ml.) was shaken with hydrogen in the presence of a 10% palladium-on-charcoal catalyst (0.6 g.) for 18 hours, filtered and evaporated to dryness. There was thus obtained as residual oil N-n-hexyl-4-methylaminobutyramide.

Workup

  1. filtrationfiltered
  2. customevaporated to dryness

Sources & evidence

ORD record
ord-8553b1ced4d744d69d41ee004cc39bf7
Source dataset
uspto-grants-1987_04
Patent number
US04659516

Reaction notes

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