Hydrazine hydrate (1:1) → HCID 13502284, compound

HRID 543115Notes

Reaction equation

HRID 543115 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:10](=O)[CH:11]([OH:16])[CH2:12][C:13](O)=[O:14])[CH:5]=[C:6]([Cl:9])[C:7]=1[CH3:8].O.[NH2:19][NH2:20]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:11]([OH:16])[CH2:12][C:13](=[O:14])[NH:19][N:20]=2)[CH:5]=[C:6]([Cl:9])[C:7]=1[CH3:8]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 13502279HCID 13502279, compound

Product 1

HCID 13502284HCID 13502284, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2.77 g of 4-(3,5-dichloro-4-methylphenyl)-3-hydroxy-4-oxobutyric acid (prepared as described in Preparation 1), 0.5 g of hydrazine hydrate (100%) and 20 ml of ethanol was stirred at room temperature for 6 hours. The resulting white powder was then collected by filtration, to give 1.77 g (yield 65%) of the desired Compound No. 7, melting at 253°-256° C.

Workup

  1. filtrationThe resulting white powder was then collected by filtration

Sources & evidence

ORD record
ord-94e1945cffd3406d9303951eb03bc937
Source dataset
uspto-grants-1987_04
Patent number
US04661486

Reaction notes

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