Hydrazine hydrate (1:1) → HCID 13502292, compound

HRID 543117Notes

Reaction equation

HRID 543117 reaction equation
O.[NH2:2][NH2:3].[Br:4][C:5]1[CH:6]=[C:7]([C:11](=O)[CH2:12][CH:13]([OH:17])[C:14](O)=[O:15])[CH:8]=[CH:9][CH:10]=1>C(O)C>[Br:4][C:5]1[CH:6]=[C:7]([C:11]2[CH2:12][CH:13]([OH:17])[C:14](=[O:15])[NH:2][N:3]=2)[CH:8]=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 13502304HCID 13502304, compound

Product 1

HCID 13502292HCID 13502292, compoundYield 58.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
65 °C

Procedure

0.25 g of hydrazine hydrate was added, at room temperature, to a mixture of 10 ml of ethanol and 1.36 g of 4-(3-bromophenyl)-2-hydroxy-4-oxobutyric acid (prepared following the procedure described in Preparation 3), and then the mixture was heated at 65° C. for 1.5 hours. The crystals which precipitated were collected by filtration at the same temperature and then washed with ethanol, giving 0.78 g (yield 58%) of the pure title compound melting at 158°-161° C.

Workup

  1. customprepared
  2. customdescribed in Preparation 3), and then the mixture
  3. customThe crystals which precipitated
  4. filtrationwere collected by filtration at the same temperature
  5. washwashed with ethanol

Sources & evidence

ORD record
ord-b15b5cda86704f2293a08706d903f15c
Source dataset
uspto-grants-1987_04
Patent number
US04661486

Reaction notes

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