2-Phenoxyethanamine → HCID 14547357, compound

HRID 543132Notes

Reaction equation

HRID 543132 reaction equation
[O:1]([CH2:8][CH2:9][NH2:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:11]([N:18]([CH2:23][C:24](O)=[O:25])[CH2:19][C:20](O)=[O:21])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C(Cl)(Cl)Cl>[O:1]([CH2:8][CH2:9][N:10]1[C:20](=[O:21])[CH2:19][N:18]([CH2:11][C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:23][C:24]1=[O:25])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 156512-PhenoxyethanamineHCID 77606N-Benzylaminodiacetic acid

Product 1

HCID 14547357HCID 14547357, compoundYield 64.8%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

2-Phenoxyethylamine (1.37 g) and N-benzyliminodiacetic acid (2.23 g) were mixed and heated to 225°, and maintained at this temperature for 15 min. After cooling, chloroform was added and the product purified by column chromatography (SiO2 /CHCl3) to give the title compound as a reddish oil (2.1 g).

Workup

  1. temperatureheated to 225°
  2. temperaturemaintained at this temperature for 15 min
  3. temperatureAfter cooling
  4. customthe product purified by column chromatography (SiO2 /CHCl3)

Sources & evidence

ORD record
ord-2627d423ca744fcdbd9458e0c850c9e6
Source dataset
uspto-grants-1987_04
Patent number
US04661489

Reaction notes

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