Amlodipine → HCID 178469320, compound

HRID 543135Notes

Reaction equation

HRID 543135 reaction equation
[NH2:1][CH2:2][CH2:3][O:4][CH2:5][C:6]1[NH:7][C:8]([CH3:28])=[C:9]([C:24]([O:26][CH3:27])=[O:25])[CH:10]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[Cl:23])[C:11]=1[C:12]([O:14][CH2:15][CH3:16])=[O:13].[CH3:29][S:30][C:31](SC)=[N:32][C:33]#[N:34].CCOCC>C(O)(C)C>[Cl:23][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[CH:10]1[C:9]([C:24]([O:26][CH3:27])=[O:25])=[C:8]([CH3:28])[NH:7][C:6]([CH2:5][O:4][CH2:3][CH2:2][NH:1][C:31](=[N:32][C:33]#[N:34])[S:30][CH3:29])=[C:11]1[C:12]([O:14][CH2:15][CH3:16])=[O:13]

Participants

5

Reactant 3

HCID 2162AmlodipineHCID 3283Diethyl EtherHCID 66289Dimethyl N-cyanodithioiminocarbonate

Product 1

HCID 178469320HCID 178469320, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

2-[2-Aminoethoxymethyl]-3-ethoxycarbonyl-4-(2-chlorophenyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine (4.3 g) and dimethyl N-cyanoimidodithiocarbonate (2 g) in isopropanol (15 ml) were allowed to stand at room temperature for 4 hours. Ether (30 ml) was then added and the mixture was stood at room temperature overnight. The crystalline precipitate was filtered, washed with ether and dried, yield of the title compound 5.0 g, m.p. 177°-179°.

Workup

  1. waitthe mixture was stood at room temperature overnight
  2. filtrationThe crystalline precipitate was filtered
  3. washwashed with ether
  4. customdried

Sources & evidence

ORD record
ord-c4030ddfd14242d2aa1fd2a59836bca5
Source dataset
uspto-grants-1987_04
Patent number
US04661485

Reaction notes

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