反应详情

To a solution of 5-[2-(hydroxy)ethylthio]imidazo[1,2-a]pyridine (9.71 g, 50 mmoles) and triethylamine (10.5 ml, 75.3 mmoles) in methylene chloride (300 ml) was added methanesulfonyl chloride (4.26 ml, 55 mmoles) with stirring under ice-cooling and the mixture was stirred under ice-cooling for 2 hours. The reaction solution was washed in turn with an aqueous saturated sodium bicarbonate solution and saturated saline and dried over anhydrous magnesium sulfate. Then, the solvent was distilled off to obtain 13.6 g of the desired product (quantitative, brown oily product).

1. temperaturecooling
2. stirringthe mixture was stirred under ice-
3. temperaturecooling for 2 hours
4. washThe reaction solution was washed in turn with an aqueous saturated sodium bicarbonate solution and saturated saline
5. dry with materialdried over anhydrous magnesium sulfate
6. distillationThen, the solvent was distilled off