1-(2,3-Epoxypropoxy)-4-(2-methoxyethoxy)benzene → HCID 15035315, compound

HRID 543212Notes

Reaction equation

HRID 543212 reaction equation
[O:1]1[CH2:16][CH:2]1[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8](OCCOC)=[CH:7][CH:6]=1.[NH2:17][CH2:18][CH2:19][NH:20][C:21]([CH:23]1[CH2:28][CH2:27][CH2:26][O:25][CH2:24]1)=[O:22].CO.[CH2:31]([O:33][C:34](=O)C)[CH3:32]>C(OCC)(=O)C>[CH3:34][O:33][CH2:31][CH2:32][C:8]1[CH:7]=[CH:6][C:5]([O:4][CH2:3][CH:2]([OH:1])[CH2:16][NH:17][CH2:18][CH2:19][NH:20][C:21]([CH:23]2[CH2:28][CH2:27][CH2:26][O:25][CH2:24]2)=[O:22])=[CH:10][CH:9]=1

Participants

5

Reactant 3

HCID 126215491-(2,3-Epoxypropoxy)-4-(2-methoxyethoxy)benzeneHCID 15035311N-(2-Aminoethyl)oxane-3-carboxamideHCID 21584119Ethylacetate methanol

Product 1

HCID 15035315HCID 15035315, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

5 g of 1-(2,3-epoxypropoxy)-4-(2-methoxyethoxy)benzene and 6 g of N-(2-aminoethyl)tetrahydropyran-3-carboxamide are heated together at 130° for 30 minutes. The mixture is allowed to cool and then dissolved in ethyl acetate and worked up in the usual manner. The title compound is obtained (M.P. 107°-108°--from methanol/ethylacetate).

Workup

  1. temperatureto cool

Sources & evidence

ORD record
ord-501dd67bf2f8419f99f1fcad60de845c
Source dataset
uspto-grants-1987_04
Patent number
US04661513

Reaction notes

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