Potassium Carbonate → HCID 21294045, compound

HRID 543226Notes

Reaction equation

HRID 543226 reaction equation
Br[CH:2]([CH2:11][CH2:12][CH3:13])[CH2:3][CH2:4][CH2:5][CH2:6][C:7]([O:9]C)=[O:8].[CH3:14][CH2:15][CH2:16][C:17]1[C:22]([OH:23])=[C:21]([C:24]([CH3:26])=[O:25])[CH:20]=[CH:19][C:18]=1[OH:27].C(=O)([O-])[O-].[K+].[K+].[OH-].[Na+]>C(O)C.CC(C)=O>[C:24]([C:21]1[CH:20]=[CH:19][C:18]([O:27][CH:2]([CH2:11][CH2:12][CH3:13])[CH2:3][CH2:4][CH2:5][CH2:6][C:7]([OH:9])=[O:8])=[C:17]([CH2:16][CH2:15][CH3:14])[C:22]=1[OH:23])(=[O:25])[CH3:26]

Participants

7

Reactant 4

HCID 11430Potassium CarbonateHCID 14798Sodium HydroxideHCID 27751982',4'-Dihydroxy-3'-propylacetophenoneHCID 21294048HCID 21294048, compound

Product 1

HCID 21294045HCID 21294045, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 702EthanolSolvent

Procedure

Following the procedures of Examples 15 E and 15F, 1.18 g. of methyl 6-bromo-nonanoate and 0.91 g. of 2,4-dihydroxy-3-propylacetophenone were reacted in the presence of 0.65 g. of potassium carbonate in 40 ml. of acetone. Hydrolysis of the ester intermediate with sodium hydroxide in aqueous ethanol gave the title product, M+ =350; NMR.

Sources & evidence

ORD record
ord-4c3ae2b8cc054269baaf62d1ca5cc75c
Source dataset
uspto-grants-1987_04
Patent number
US04661505

Reaction notes

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