反应详情

To a solution containing 5.2 g (8.7 mmol) of N-[3-[2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy]acetylthio-2-methylpropanoyl]-N-cyclopentyl glycine t-butyl ester in 100 ml of methylene chloride was added 9.0 ml (117 mmol) of trifluoroacetic acid. After 12 hours the reaction mixture was carefully concentrated in vacuo and the residue was chromatographed via HPLC [methylene chloride/ether/acetic acid (88/10/2.5)]to afford 2.4 g (52%) of N-[3-[2,3-dichloro-4-(2-methylene-1-oxobutyl) phenoxy] acetylthio-2methylpropanoyl]-N-cyclopentyl glycine as a glass.

1. concentrationAfter 12 hours the reaction mixture was carefully concentrated in vacuo
2. customthe residue was chromatographed via HPLC [methylene chloride/ether/acetic acid (88/10/2.5)]to