反应详情

A solution of 5-[2-(methylsulfonyloxy)ethylthio]imidazo[1,2-a]pyridine (2.18 g, 8 mmoles), triethylamine (2.24 ml, 16 mmoles) and a 40% methylamine-methanol solution (20 ml) in chloroform (20 ml) was heated at reflux for 3 hours. The reaction solution was washed with an aqueous 3N-sodium hydroxide solution and dried over anhydrous magnesium sulfate. After the solvent was distilled off, the residue was purified by column chromatography (eluent: methanol/chloroform=1:10) to obtain 781 mg of the desired product (47.1%, light brown oily product).

1. temperatureat reflux for 3 hours
2. washThe reaction solution was washed with an aqueous 3N-sodium hydroxide solution
3. dry with materialdried over anhydrous magnesium sulfate
4. distillationAfter the solvent was distilled off
5. customthe residue was purified by column chromatography (eluent: methanol/chloroform=1:10)