Octylamine → HCID 20206211, compound

HRID 543311Notes

Reaction equation

HRID 543311 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[C:9]([CH3:18])([CH3:17])[CH2:10][CH2:11][CH2:12][C:13]([O:15]C)=O.[CH2:19]([NH2:27])[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26]>CCOCC>[CH2:19]([NH:27][C:13](=[O:15])[CH2:12][CH2:11][CH2:10][C:9]([C:3]1[CH:4]=[CH:5][C:6]([OH:8])=[CH:7][C:2]=1[OH:1])([CH3:18])[CH3:17])[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26]

Participants

4

Reactant 2

HCID 8143OctylamineHCID 20206153HCID 20206153, compound

Product 1

HCID 20206211HCID 20206211, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

2.5 Parts of methyl 5-(2',4'-dihydroxyphenyl)-5-methyl-hexanoate and 5.0 parts of n-octylamine are sealed into a glass Carius tube for 3 days at 120° C. The cooled reaction mixture is taken up in ether, washed first with dilute hydrochloric acid until free of the excess octylamine, and then with water. After removing the ether, the residual oil, on dilution with 40°-60° C. petroleum ether containing a little ether yields 5-(2',4'-dihydroxyphenyl)-5-methyl-hexanoic acid-n-octylamide m.p. 110°-113° C. with the following percentage composition by weight.

Workup

  1. customThe cooled reaction mixture
  2. washwashed first with dilute hydrochloric acid until free of the excess octylamine
  3. customAfter removing the ether

Sources & evidence

ORD record
ord-63e7e0d3390b48d1b3a1a3c5515b3668
Source dataset
uspto-grants-1987_04
Patent number
US04661601

Reaction notes

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