Bromine → 3,3-Bisfluoromethyl-1-bromo-butan-2-one

HRID 543366Notes

Reaction equation

HRID 543366 reaction equation
[Br:1]Br.[F:3][CH2:4][C:5]([CH2:10][F:11])([CH3:9])[C:6](=[O:8])[CH3:7]>C(Cl)Cl>[F:3][CH2:4][C:5]([CH2:10][F:11])([CH3:9])[C:6](=[O:8])[CH2:7][Br:1]

Participants

4

Reactant 2

HCID 24408BromineHCID 130194334-Fluoro-3-(fluoromethyl)-3-methylbutan-2-one

Product 1

HCID 130194343,3-Bisfluoromethyl-1-bromo-butan-2-one

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

51 ml (1 mol) of bromine were added dropwise to 136 g (1 mol) of 3,3-bisfluoromethylbutane-2-one in 700 ml of methylene chloride such that decoloration was continuous. The solvent was then distilled off under a water pump vacuum. An almost quantitative yield of crude 3,3-bisfluoromethyl-1-bromo-butan-2-one was obtained as an oil, which could be further reacted directly.

Workup

  1. distillationThe solvent was then distilled off under a water pump vacuum

Sources & evidence

ORD record
ord-f771d13f0090404cafd1ea390e83f465
Source dataset
uspto-grants-1987_04
Patent number
US04661640

Reaction notes

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