N-Methylol-alpha-chloroacetamide → HCID 13210257, compound

HRID 543374Notes

Reaction equation

HRID 543374 reaction equation
[CH3:1][C:2]([C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[C:7]([S:12]([CH3:15])(=[O:14])=[O:13])[CH:6]=1)([CH3:4])[CH3:3].[Cl:16][CH2:17][C:18]([NH:20][CH2:21]O)=[O:19]>S(=O)(=O)(O)O>[Cl:16][CH2:17][C:18]([NH:20][CH2:21][C:9]1[CH:10]=[C:5]([C:2]([CH3:1])([CH3:3])[CH3:4])[CH:6]=[C:7]([S:12]([CH3:15])(=[O:14])=[O:13])[C:8]=1[OH:11])=[O:19]

Participants

4

Reactant 2

HCID 62466N-Methylol-alpha-chloroacetamideHCID 127215634-tert-Butyl-2-(methanesulfonyl)phenol

Product 1

HCID 13210257HCID 13210257, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

13.5 g (0.06 mol) of 4-(1,1-dimethylethyl)-2-methylsulfonylphenol are dissolved in 100 ml of concentrated sulfuric acid. 6.63 g (0.054 mol) of 2-chloro-N-hydroxymethylacetamide are added and the mixture is stirred at room temperature for 10 minutes. It is then poured onto ice-water and the crude product is filtered off with suction and recrystallized from toluene.

Workup

  1. additionIt is then poured onto ice-water
  2. filtrationthe crude product is filtered off with suction
  3. customrecrystallized from toluene

Sources & evidence

ORD record
ord-9b23d3b4ebcd48de8e478e3ffb461140
Source dataset
uspto-grants-1987_04
Patent number
US04661636

Reaction notes

Loading…