Hydrochloric Acid → 80518-56-5

Participants

Reaction Conditions

Reaction Steps

In 50 ml of chloroform was dissolved 2.9 g (0.01 mole) of 1-(4-methoxyphenyl)-4-diethylcarbamoylpiperazine, and the solution was saturated with gaseous hydrogen chloride and stirred at 40° C. for 3 hours. The solvent was removed by distillation under reduced pressure. The residue was mixed with 30 ml of a mixed solvent of ethyl acetate and methanol. The insoluble substance was removed, and the precipitated crystal was recovered by filtration to obtain 1.7 g of 1-(4-methoxyphenyl)-4-diethylcarbamoylpiperazine hydrochloride having a melting point of 174° to 184° C. The yield was 52.1%. The elementary analysis values are as follows.

Provenance & Evidence