Hydrochloric Acid → 80518-56-5

HRID 543478Notes

Reaction equation

HRID 543478 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][N:12]([C:15](=[O:21])[N:16]([CH2:19][CH3:20])[CH2:17][CH3:18])[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.[ClH:22]>C(Cl)(Cl)Cl>[ClH:22].[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N:9]2[CH2:10][CH2:11][N:12]([C:15](=[O:21])[N:16]([CH2:19][CH3:20])[CH2:17][CH3:18])[CH2:13][CH2:14]2)=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 422756N,N-diethyl-4-(4-methoxyphenyl)piperazine-1-carboxamide

Product 1

HCID 2046151280518-56-5Yield 52.1%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Conditions

Temperature
40 °C

Procedure

In 50 ml of chloroform was dissolved 2.9 g (0.01 mole) of 1-(4-methoxyphenyl)-4-diethylcarbamoylpiperazine, and the solution was saturated with gaseous hydrogen chloride and stirred at 40° C. for 3 hours. The solvent was removed by distillation under reduced pressure. The residue was mixed with 30 ml of a mixed solvent of ethyl acetate and methanol. The insoluble substance was removed, and the precipitated crystal was recovered by filtration to obtain 1.7 g of 1-(4-methoxyphenyl)-4-diethylcarbamoylpiperazine hydrochloride having a melting point of 174° to 184° C. The yield was 52.1%. The elementary analysis values are as follows.

Workup

  1. customThe solvent was removed by distillation under reduced pressure
  2. additionThe residue was mixed with 30 ml of a mixed solvent of ethyl acetate and methanol
  3. customThe insoluble substance was removed
  4. filtrationthe precipitated crystal was recovered by filtration

Sources & evidence

ORD record
ord-abe116bf909e4108a5ce720dab930354
Source dataset
uspto-grants-1984_05
Patent number
US04446133

Reaction notes

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