Sodium Hydroxide → HCID 178513314, compound

HRID 543485Notes

Reaction equation

HRID 543485 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][C:10]([NH:20][O:21][CH:22]1[CH2:27][CH2:26][CH2:25][CH2:24][O:23]1)=[N:11]C(=O)C1C=CC=CC=1.[OH-].[Na+]>O.C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][C:10]([NH2:11])=[N:20][O:21][CH:22]1[CH2:27][CH2:26][CH2:25][CH2:24][O:23]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178523923HCID 178523923, compound

Product 1

HCID 178513314HCID 178513314, compoundYield 87.5%

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Procedure

38.5 g 1-(2,6-dichlorophenyl)-2-benzoyl-3-tetrahydropyranyloxyguanidine are heated to a boil with 900 ml 5% NaOH (in a mixture water/ethanol 1:1) for 2 hours. After cooling, 25.1 g 1-(2,6-dichlorophenyl)-2-tetrahydropyranyloxyguanidine having a melting point of 178°-180° C. is obtained.

Workup

  1. temperatureAfter cooling

Sources & evidence

ORD record
ord-85e6a2c08c844689960b1ce4947357e5
Source dataset
uspto-grants-1984_05
Patent number
US04446142

Reaction notes

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