HCID 178513314, compound → HCID 178513437, compound

HRID 543486Notes

Reaction equation

HRID 543486 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][C:10]([NH2:19])=[N:11][O:12]C1CCCCO1>Cl>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][C:10]([NH2:19])=[N:11][OH:12]

Participants

3

Reactant 1

HCID 178513314HCID 178513314, compound

Product 1

HCID 178513437HCID 178513437, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

17.2 g 1-(2,6-dichlorophenyl)-2-tetrahydropyranyloxyguanidine are hydrolyzed with 150 ml ethanolic hydrochloric acid for 15 hours at room temperature. After evaporation of the ethanol, the residue is dissolved in water, neutralized with 2-N NaOH, and extracted with methylene chloride. 10.2 g 1-(2,6-dichlorophenyl)-2-hydroxyguanidine having a melting point of 113° C. (decomp.) is obtained.

Workup

  1. customAfter evaporation of the ethanol
  2. dissolutionthe residue is dissolved in water
  3. extractionextracted with methylene chloride

Sources & evidence

ORD record
ord-359a99a3d0664439be31a43df4effc07
Source dataset
uspto-grants-1984_05
Patent number
US04446142

Reaction notes

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