反应详情

A mixture of 2-acetamido-5-chloro-3-nitrobenzotrifluoride (354 mg, 1.252 mmol) in concentrated HCl (3 mL) was refluxed overnight, and it was extracted by ethyl acetate (2×3 mL). The extract was dried (Mg2SO4) and evaporated to give 250 mg (83%) of 2-amino-5-chloro-3-nitrobenzotrifluoride. 1H NMR (CDCl3): δ6.663 (s, 2H), 7.717 (s, 1H), 8.360 (s, 1H).

1. temperaturewas refluxed overnight
2. extractionit was extracted by ethyl acetate (2×3 mL)
3. dry with materialThe extract was dried (Mg2SO4)
4. customevaporated