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HRID543545

反应详情

EQUATION

反应方程式

HRID 543545 的结构方程式

REACTANTS

反应物

4
结构：O
HCID962

Water

H2O

结构：CC(=O)OCC1=C(C(=O)O)N2C(=O)[C@@H](N)[C@H]2SC1
HCID441328

7-Aminocephalosporanic acid

C10H12N2O5S

结构：O=P(Cl)(Cl)OP(=O)(Cl)Cl
HCID4432411

Diphosphoryl tetrachloride

Cl4O3P2

结构：CCOC(=O)CSc1nnc(S)s1
HCID178473173

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)CSc1nnc(SCC2=C(C(=O)O)N3C(=O)C(N)[C@H]3SC2)s1
HCID70463237

未命名化合物

收率 91.9%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC#N
溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

The procedure was carried out in accordance with Example 22, while utilizing 1.36 g of 7-ACA, 0.36 g of water, 8.0 ml of acetonitrile, 1.54 g of 2-ethoxycarbonylmethylthio-5-mercapto-1,3,4-thiadiazole and 5.04 g of diphosphoryl tetrachloride, and there was obtained 2.06 g (91.8%) of 7-amino-3-(2-ethoxycarbonylmethylthio-1,3,4-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid.