6a,7,8,9-tetrahydropyrido[3,2-e]pyrrolo[1,2-a]pyrazin-6(5H)-one → 5,6,6a,7,8,9-Hexahydropyrido[3,2-e]pyrrolo[1,2-a]pyrazine

HRID 543548Notes

Reaction equation

HRID 543548 reaction equation
[N:1]1[C:10]2[N:9]3[CH2:11][CH2:12][CH2:13][CH:8]3[C:7](=O)[NH:6][C:5]=2[CH:4]=[CH:3][CH:2]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[N:1]1[C:10]2[N:9]3[CH2:11][CH2:12][CH2:13][CH:8]3[CH2:7][NH:6][C:5]=2[CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 27661876a,7,8,9-tetrahydropyrido[3,2-e]pyrrolo[1,2-a]pyrazin-6(5H)-oneHCID 21226445Aluminium lithium hydride

Product 1

HCID 133420945,6,6a,7,8,9-Hexahydropyrido[3,2-e]pyrrolo[1,2-a]pyrazine

Procedure

Following the procedure of Example 3, 6a,7,8,9-tetrahydropyrido[3,2-e]pyrrolo[1,2-a]pyrazin-6(5H)-one is reduced with lithium aluminum hydride to afford the title compound as the hydrochloride salt, m.p. 198°-201° C.

Sources & evidence

ORD record
ord-4fce1c8cdd34408a9a15a6f467e743cb
Source dataset
uspto-grants-1984_05
Patent number
US04446323

Reaction notes

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