反应详情

温度

130 °C

A mixture of 1,2-dichloro-3-(trifluoromethyl)benzene (21.5 g), N-[(±)-2-(4-hydroxyphenoxy)propionyl]isoxazolidine (23.7 g) which was prepared as in Example 3, anhydrous potassium carbonate (14.5 g) and dimethylsulfoxide (200 ml) was stirred at 130° C. for 3 hours. After the mixture was cooled, water and benzene were added thereto to form two layers. The organic layer thus separated was washed with 1 N aqueous sodium hydroxide solution and then with water and dried over anhydrous sodium sulfate. Removal of the solvent by a distillation in vacuo gave N-[(±)-2-[4-(2-chloro-4-trifluoromethylphenoxy)phenoxy]propionyl]isoxazolidine (39.9 g) as a pale brown crystalline solid. Recrystallization from a mixture of n-hexane and ethyl acetate afforded a white crystalline solid. m.p. 66.5°-67.5° C.

1. temperatureAfter the mixture was cooled
2. customto form two layers
3. customThe organic layer thus separated
4. washwas washed with 1 N aqueous sodium hydroxide solution
5. dry with materialwith water and dried over anhydrous sodium sulfate
6. customRemoval of the solvent
7. distillationby a distillation in vacuo