Sodium hydride → HCID 20184016, compound

HRID 543632Notes

Reaction equation

HRID 543632 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[NH:10][C:9]2[N:17]=[CH:18][CH:19]=[CH:20][C:8]=2[N:7]=1.[H-].[Na+].[CH3:23][N:24]([CH3:29])[CH2:25][CH2:26][CH2:27]Cl>>[CH3:23][N:24]([CH3:29])[CH2:25][CH2:26][CH2:27][N:10]1[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[C:6]([C:2]2[S:1][CH:5]=[CH:4][CH:3]=2)=[N:7][C:8]2[CH:20]=[CH:19][CH:18]=[N:17][C:9]1=2

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 669603-Chloro-N,N-dimethyl-1-propanamineHCID 135626373HCID 135626373, compound

Product 1

HCID 20184016HCID 20184016, compound

Procedure

Following the procedure of Example 23, 6-(2-thienyl)11H-pyrido[2,3-b][1,4]benzodiazepine is reacted with sodium hydride followed by reaction with 3-dimethylaminopropyl chloride to give the title compound.

Sources & evidence

ORD record
ord-cb3014132b744963be2ba57b3c621863
Source dataset
uspto-grants-1984_05
Patent number
US04447361

Reaction notes

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