Sodium hydride → N,N-Dimethyl-6-(3-thienyl)-11H-pyrido[2,3-b][1,4]benzodiazepine-11-propanamine

HRID 543633Notes

Reaction equation

HRID 543633 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([C:6]2[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[NH:10][C:9]3[N:17]=[CH:18][CH:19]=[CH:20][C:8]=3[N:7]=2)=[CH:2]1.[H-].[Na+].[CH3:23][N:24]([CH3:29])[CH2:25][CH2:26][CH2:27]Cl>>[CH3:23][N:24]([CH3:29])[CH2:25][CH2:26][CH2:27][N:10]1[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[C:6]([C:3]2[CH:4]=[CH:5][S:1][CH:2]=2)=[N:7][C:8]2[CH:20]=[CH:19][CH:18]=[N:17][C:9]1=2

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 669603-Chloro-N,N-dimethyl-1-propanamineHCID 1356263706-(3-thienyl)11H-pyrido[2,3-b][1,4]benzodiazepine

Product 1

HCID 20184008N,N-Dimethyl-6-(3-thienyl)-11H-pyrido[2,3-b][1,4]benzodiazepine-11-propanamine

Procedure

Following the procedure of Example 23, 6-(3-thienyl)11H-pyrido[2,3-b][1,4]benzodiazepine is reacted with sodium hydride followed by reaction with 3-dimethylaminopropyl chloride to give the title compound.

Sources & evidence

ORD record
ord-4135bf2cd05442c882ecab2943b7d9a7
Source dataset
uspto-grants-1984_05
Patent number
US04447361

Reaction notes

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