Sodium hydride → HCID 20184112, compound

HRID 543634Notes

Reaction equation

HRID 543634 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[NH:11][C:10]2[N:18]=[CH:19][CH:20]=[CH:21][C:9]=2[N:8]=1.[H-].[Na+].[CH3:24][N:25]([CH3:30])[CH2:26][CH2:27][CH2:28]Cl>>[CH3:24][N:25]([CH3:30])[CH2:26][CH2:27][CH2:28][N:11]1[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[C:7]([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)=[N:8][C:9]2[CH:21]=[CH:20][CH:19]=[N:18][C:10]1=2

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 669603-Chloro-N,N-dimethyl-1-propanamineHCID 135626381HCID 135626381, compound

Product 1

HCID 20184112HCID 20184112, compound

Procedure

Following the procedure of Example 23, 6-(2-pyridinyl)11H-pyrido[2,3-b][1,4]benzodiazepine is reacted with sodium hydride followed by reaction with 3-dimethylaminopropyl chloride to give the title compound.

Sources & evidence

ORD record
ord-d5d4a0c4bef646e3a6bf13779b125ff9
Source dataset
uspto-grants-1984_05
Patent number
US04447361

Reaction notes

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