Sodium Hydroxide → HCID 178482377, compound

HRID 543660Notes

Reaction equation

HRID 543660 reaction equation
[CH3:1][NH:2][C:3]1[N:8]=[C:7]([OH:9])[C:6]([C:10]([O:12]CC)=[O:11])=[CH:5][N:4]=1.[OH-].[Na+]>O>[CH3:1][NH:2][C:3]1[N:8]=[C:7]([OH:9])[C:6]([C:10]([OH:12])=[O:11])=[CH:5][N:4]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178469832HCID 178469832, compound

Product 1

HCID 178482377HCID 178482377, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-Methylamino-5-ethoxycarbonyl-4-hydroxypyrimidine (360 mg 1.9 mmol) was hydrolysed in boiling water (10 ml) with NaOH (0.19 g, 4.7 mmol) for 2 h. Cooling and acidification to pH 2 yielded the named product as a precipitate (261 mg, 80%).

Workup

  1. customfor 2 h
  2. temperatureCooling
  3. customacidification to pH 2 yielded the named product as a precipitate (261 mg, 80%)

Sources & evidence

ORD record
ord-b4ae96302c0f45ac81125c444da4504e
Source dataset
uspto-grants-1984_05
Patent number
US04447422

Reaction notes

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