1-Propanamine, acetate → HCID 178456849, compound

HRID 543661Notes

Reaction equation

HRID 543661 reaction equation
CS[C:3]1[N:8]=[C:7]([OH:9])[C:6]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:5][N:4]=1.C(O)(=O)C.[CH2:19]([NH2:22])[CH2:20][CH3:21]>O>[CH2:19]([NH:22][C:3]1[N:8]=[C:7]([OH:9])[C:6]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:5][N:4]=1)[CH2:20][CH3:21]

Participants

4

Reactant 2

HCID 122036631-Propanamine, acetateHCID 178418871HCID 178418871, compound

Product 1

HCID 178456849HCID 178456849, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-Methylthio-5-ethoxycarbonyl-4-hydroxypyrimidine (2 mmol, 428 mg) was heated on an oil bath at 160° C. with n-propylamine acetate (1 ml) for 1 hour. The semi solid was cooled and then treated with 50 ml boiling water, and the solid product was filtered off (yield 400 mg, 88%)

Workup

  1. temperatureThe semi solid was cooled
  2. additiontreated with 50 ml
  3. filtrationthe solid product was filtered off (yield 400 mg, 88%)

Sources & evidence

ORD record
ord-29a8e092abdd40efa21bc881d67aaf27
Source dataset
uspto-grants-1984_05
Patent number
US04447422

Reaction notes

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