反应详情

2-Methylthio-5-ethoxycarbonyl-4-hydroxypyrimidine (2 mmol, 428 mg) was heated on an oil bath at 160° C. with n-propylamine acetate (1 ml) for 1 hour. The semi solid was cooled and then treated with 50 ml boiling water, and the solid product was filtered off (yield 400 mg, 88%)

1. temperatureThe semi solid was cooled
2. additiontreated with 50 ml
3. filtrationthe solid product was filtered off (yield 400 mg, 88%)