Formaldehyde → HCID 178487896, compound

HRID 543682Notes

Reaction equation

HRID 543682 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][CH:3]=1.[CH2:14]=[O:15]>[OH-].[Na+]>[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][C:3]=1[CH2:14][OH:15]

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 178487890HCID 178487890, compound

Product 1

HCID 178487896HCID 178487896, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

4-Hydroxy-6-methoxyquinoline was reacted with formaldehyde in aqueous sodium hydroxide (initially at 40°-50°, then kept at 60° for 18 hours) to give the novel compound 4-hydroxy-3-hydroxymethyl-6-methoxyquinoline, m.p. 327°-334°.

Sources & evidence

ORD record
ord-403c408712b7453687c262c06be1dffe
Source dataset
uspto-grants-1984_05
Patent number
US04447435

Reaction notes

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