Methyl iodide → HCID 13247791, compound

HRID 543709Notes

Reaction equation

HRID 543709 reaction equation
[N:1]1([CH:7]([C:18]2[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[O:20][N:19]=2)[C:8]([O:10][CH:11]2[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]2)=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:27][I:28]>CC(C)=O>[I-:28].[CH3:17][N+:14]1([CH3:27])[CH2:13][CH2:12][CH:11]([O:10][C:8](=[O:9])[CH:7]([N:1]2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2)[C:18]2[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[O:20][N:19]=2)[CH2:16][CH2:15]1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 13247738HCID 13247738, compound

Product 1

HCID 13247791HCID 13247791, compoundYield 78.7%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 1-methyl-4-piperidyl 2-piperidino-2-(1,2-benzisoxazol-3-yl)acetate (1 g), methyl iodide (2.5 g), and acetone (10 ml) was allowed to stand at room temperature for 5 hours. The resulting crystals were recrystallized from ethanol-methanol to give 1,1-dimethyl-4-[2-piperidino-2-(1,2-benzisoxazol-3-yl)acetoxy]piperidinium iodide (1.1 g), m.p. 176°-178° C.

Workup

  1. customThe resulting crystals were recrystallized from ethanol-methanol

Sources & evidence

ORD record
ord-92edaddd324a4ffe9590339a5a3c19a9
Source dataset
uspto-grants-1984_05
Patent number
US04447439

Reaction notes

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