HCID 12052140, compound → HCID 13883776, compound

HRID 543757Notes

Reaction equation

HRID 543757 reaction equation
[N+:1]([C:4]1[CH:8]=[CH:7][N:6]([CH2:9][CH2:10][CH2:11][CH2:12][C:13]#[N:14])[N:5]=1)([O-])=O>O1CCCC1.[Pd]>[NH2:1][C:4]1[CH:8]=[CH:7][N:6]([CH2:9][CH2:10][CH2:11][CH2:12][C:13]#[N:14])[N:5]=1

Participants

4

Reactant 1

HCID 12052140HCID 12052140, compound

Product 1

HCID 13883776HCID 13883776, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 5-(3-nitropyrazol-1-yl)valeronitrile (9.16 g.) in dry tetrahydrofuran (200 ml.) was added 5% w/w palladium on carbon (1.8 g.). The mixture was stirred at 20° under an atmosphere of hydrogen. 3.2 Liters of hydrogen were absorbed over 4 hours. The catalyst was filtered off and the filtrate was evaporated in vacuo to give 5-(3-aminopyrazol-1-yl)valeronitrile as an oil.

Workup

  1. custom3.2 Liters of hydrogen were absorbed over 4 hours
  2. filtrationThe catalyst was filtered off
  3. customthe filtrate was evaporated in vacuo

Sources & evidence

ORD record
ord-3a914a43b9874802bc8d9da910aa7b48
Source dataset
uspto-grants-1984_05
Patent number
US04447441

Reaction notes

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