HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → HCID 20202831, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | HCID 20202856 | HCID 20202856 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 20202831 | HCID 20202831 | — |
Reaction Steps
Methyl 3-[2-(2-[2,2,2-trifluoroethyl]guanidino)thiazol-4-ylmethylthio]propionate (0.5 g.) in EtOH (20 ml.) was treated with 33% w/v ethanolic methylamine (7 ml.) and stirred for 18 hours at room temperature. The solution was evaporated and the residue crystallised from aqueous EtOH to give N-methyl-3-[2-(2-[2,2,2-trifluoroethyl]guanidino)thiazol-4-ylmethylthio]propionamide (0.35 g.), m.p. 152°-154° (73%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04447441 |
| Source dataset | uspto-grants-1984_05 |
| ORD ID | ord-a8a3a380e8944cba8785fe3efab55789 |
| Source note | uspto-grants-1984_05 |