Methylamine → HCID 20202831, compound

HRID 543778Notes

Reaction equation

HRID 543778 reaction equation
[F:1][C:2]([F:22])([F:21])[CH2:3][N:4]=[C:5]([NH2:20])[NH:6][C:7]1[S:8][CH:9]=[C:10]([CH2:12][S:13][CH2:14][CH2:15][C:16]([O:18]C)=O)[N:11]=1.[CH3:23][NH2:24]>CCO>[CH3:23][NH:24][C:16](=[O:18])[CH2:15][CH2:14][S:13][CH2:12][C:10]1[N:11]=[C:7]([NH:6][C:5]([NH2:20])=[N:4][CH2:3][C:2]([F:1])([F:22])[F:21])[S:8][CH:9]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 20202856HCID 20202856, compound

Product 1

HCID 20202831HCID 20202831, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Methyl 3-[2-(2-[2,2,2-trifluoroethyl]guanidino)thiazol-4-ylmethylthio]propionate (0.5 g.) in EtOH (20 ml.) was treated with 33% w/v ethanolic methylamine (7 ml.) and stirred for 18 hours at room temperature. The solution was evaporated and the residue crystallised from aqueous EtOH to give N-methyl-3-[2-(2-[2,2,2-trifluoroethyl]guanidino)thiazol-4-ylmethylthio]propionamide (0.35 g.), m.p. 152°-154° (73%).

Workup

  1. customThe solution was evaporated
  2. customthe residue crystallised from aqueous EtOH

Sources & evidence

ORD record
ord-a8a3a380e8944cba8785fe3efab55789
Source dataset
uspto-grants-1984_05
Patent number
US04447441

Reaction notes

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