反应详情

To a solution of 5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine (9.63 g, 49.8 mmoles) and triethylamine (7.64 ml) in methylene chloride (150 ml) was added methanesulfonyl chloride (3.85 ml, 49.7 mmoles) with stirring under ice-cooling and was stirred under ice-cooling for 1 hour. The reaction solution was poured into water and stirred. Then, the crystals precipitated were filtered off, washed with water and dried to obtain 10.53 g of the desired product (77.9%, colorless crystals).

1. temperaturecooling
2. stirringwas stirred under ice-
3. temperaturecooling for 1 hour
4. stirringstirred
5. customThen, the crystals precipitated
6. filtrationwere filtered off
7. washwashed with water
8. customdried